Health Condition 1: C509- Malignant neoplasm of breast of unspecified site
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Sponsors
ACTREC, Tata Memorial Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1. Women of age 18-65 years who are radiologically or histopathologically diagnosed with breast cancer of any receptor expression / subtype. (including ER+, PR+, HER2+, and triplenegative breast cancer [TNBC]). 2. Who are eligible for upfront surgery and who consent for bio banking of their tumour and adjacent normal tissue from primary tumour site at time of diagnostic biopsy or surgical resection
Exclusion criteria
Exclusion criteria: 1.Women who are socio-vulnerable (unable to comprehend study, not deemed mentally fit to take a decision on their own) 2. Women who don t consent for biopsy 3.Women whose tumour tissue does not have any tumour content and/or are not diagnosed with cancer on histopathological examination of biopsy specimen 4.Patients with radiologically or histologically confirmed metastatic breast cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1 To fabricate and optimize the static and microfluidic devices and develop patient derived in vitro multicellular tumoroid model. 2. Validation and cryo-preservation of tumoroid for their potential commercial applications 3. Drug Screening and Functional AssaysTimepoint: 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Molecular Characterization: Perform Western blot or immunohistochemistry on organoids to study the effect of chosen therapeutic molecules on epithelial cells, CAFs, and immune cellsTimepoint: 2 years | — |
Countries
India
Contacts
Public ContactDr Anbarasan Sekar
Advanced Centre for Treatment Research and Education in Cancer Tata Memorial Centre
Outcome results
None listed