Comparing Two Medicines Palonosetron and Ondansetron to Prevent Vomiting After Laparoscopic Surgery in Women

Comparison of Palonosetron with Ondansetron for prevention of Postoperative Nausea and Vomiting in Female patients undergoing Laparoscopic Surgeries - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099662

Enrollment

156

Registered

2025-12-22

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R198- Other specified symptoms and signsinvolving the digestive system and abdomen

Interventions

Intervention1: Inj.Palonosetron 1mcg/kg iv: Female patients undergoing Laparoscopic abdominal surgeries are given Inj Palonosetron 1mcg/kg iv before induction of general anaesthesia Control Interventi

Eligibility

Inclusion criteria

Inclusion criteria: Female patients undergoing Laparoscopic Abdominal surgeries of ASA I and II

Exclusion criteria

Exclusion criteria: 1. BMI more than or equal to 30kg / m2 2. Patients with a known history of Gastric Esophageal Reflux Disease 3.Allergic to Study drugs

Design outcomes

Primary

Measure	Time frame
To measure the incidence of postoperative nausea and vomiting with the use of Palonosetron and Ondansetron in first 24 hrs following Laparoscopic surgeries in female patients using PONV scoring systemTimepoint: 0 hrs, 2 hrs, 6 hrs , 12 hrs, 24 hrs	—

Secondary

Measure	Time frame
1. To assess the need for rescue antiemetics 2. To evaluate Patient Satisfaction score regarding PONV management in both groupsTimepoint: 0 hrs , 2 hrs, 6 hrs, 12 hrs, 24 hrs	—

Countries

India

Contacts

Public ContactDr Dharam Singh Meena

Vardhman Mahavir medical college and Safdarjung hospital

dharams_meena@yahoo.com9910277131

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026