This study is done to compare the lignocaine in the nebulaization(inhalational) form and lignocaine in the spray form for decreasing the response that is increased blood pressure and heart rate to endotracheal intubation in patients undergoing elective surgery

Comparative Evaluation of Lignocaine Nebulization versus Lignocaine Spray for Attenuation of Pressor Response to Endotracheal Intubation in Patients Undergoing Elective Surgery - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099627

Enrollment

Registered

2025-12-22

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nebulized Lignocaine: Lignocaine nebulized in dose of 1.5mg/kg of 4% lignocaine given via nebulizer over 10 minutes given once before intubation Control Intervention1: Lignocaine spray:

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade 1 and 2, elective surgeries under general anesthesia requiring endotracheal intubation

Exclusion criteria

Exclusion criteria: Known allergy to lignocaine, anticipated difficult airway, cardiovascular or cerebrovascular disease, any recent respiratory infection or disease, use of beta blocker or autonomic drugs, pregnant/ lactating mother

Design outcomes

Primary

Measure	Time frame
Mean and proportion of hemodynamic responseTimepoint: immediately, at 1,3,5,7,10 min after intubation	—

Secondary

Measure	Time frame
Percentage and proportion of rate of complications ( bronchospasm, lignocaine toxicity, allergic reaction)Timepoint: During and after intubation	—

Countries

India

Contacts

Public ContactDr Garima Jindal

Adesh Institute of Medical Sciences and Research, BATHINDA

garimajindal90@gmail.com9646486062

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026