Comparing Heart Monitoring Methods in Heart Bypass Surgery: A Study on Propofol vs. Sevoflurane

Assessment of Cardiac Output During Off-Pump Coronary Artery Bypass Grafting: A Comparative Analysis of Propofol vs. Sevoflurane Using Near Infrared Spectroscopy - NIL

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099580

Enrollment

Registered

2025-12-22

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery

Interventions

Intervention1: PROPOFOL TIVA V/S SEVOFLURANE: TO COMPARE THE CARDIAC OUTPUT DERIVED BY TRANS ESOPHAGEAL ECHO WITH MEAN REGIONAL OXYGEN SATURATION VALUES IN TWO GROUPS PROPOFOL VS SEVOFLURANE IN ADULT

Eligibility

Inclusion criteria

Inclusion criteria: Adult patient 40-80 years of age undergoing off pump coronary artery bypass grafting. NYHA III or less LVEF more than 30% Elective OPCAB

Exclusion criteria

Exclusion criteria: Pre-existing cerebrovascular insufficiency. Patients who have contra-indication to TEE probe insertion. Patients who are converted to on pump CABG . Poor LV function EF less than 30% Significant carotid artery stenosis. Previous stroke or head injury. Seizure Psychiatric illness Decompensated heart failure Emergency surgeries. Severely impaired liver and renal function.

Design outcomes

Primary

Measure	Time frame
Assess Cardiac Output During Off-Pump Coronary Artery Bypass Grafting Using Near Infrared Spectroscopy between two different anesthetic agents propofol and sevoflurane.Timepoint: AT BASELINE WHEN PATIENT IS AWAKE, AFTER INDUCTION, AT POSITIONG FOR LEFT ANTERIOR DESCENDING GRAFTING, AT POSITIONG FOR LEFT CIRCUMFLEX GRAFTING, AT POSITIONING FOR RIGHT CORONARY ARTERY GRAFTING, POST SURGERY.	—

Secondary

Measure	Time frame
Cardiac output & NIRS values positioning of LAD, LCX or OM, PDA or RCA, in Group-P & Group-S Percentage of fall in NIRS from the baseline. Intervention performed. Success rates of the intervention. Vasoactive ionotropic score, serum lactate clearance trend, Post-operative major adverse cardiac events, Length of ICU stay. Length of Hospital stay.Timepoint: AT BASELINE WHEN PATIENT IS AWAKE, AFTER INDUCTION, AT POSITIONG FOR LEFT ANTERIOR DESCENDING GRAFTING, AT POSITIONG FOR LEFT CIRCUMFLEX GRAFTING, AT POSITIONING FOR RIGHT CORONARY ARTERY GRAFTING, POST SURGERY.	—

Measure

Time frame

Cardiac output & NIRS values positioning of LAD, LCX or OM, PDA or RCA, in Group-P & Group-S Percentage of fall in NIRS from the baseline. Intervention performed. Success rates of the intervention. Vasoactive ionotropic score, serum lactate clearance trend, Post-operative major adverse cardiac events, Length of ICU stay. Length of Hospital stay.Timepoint: AT BASELINE WHEN PATIENT IS AWAKE, AFTER INDUCTION, AT POSITIONG FOR LEFT ANTERIOR DESCENDING GRAFTING, AT POSITIONG FOR LEFT CIRCUMFLEX GRAFTING, AT POSITIONING FOR RIGHT CORONARY ARTERY GRAFTING, POST SURGERY.

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Countries

India

Contacts

Public ContactShanthi Sharmiya R

Sree Chitra Tirunal Institute For Medical Sciences and Technology, Trivandrum

Unnikp@sctimst.ac.in9446177521

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026