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Assessing the response to treatment in the form of fluid bolus by using internal jugular vein distensibility index in long term liver disease patients with shock on ventilator A prospective observational study

Assessment of volume responsiveness using internal jugular vein distensibility index(IJV DI) in mechanically ventilated patients with decompensated chronic liver disease(DCLD) and septic shock A prospective observational study - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/12/099513
Enrollment
150
Registered
2025-12-19
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K740- Hepatic fibrosis

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil

Sponsors

Institute of liver and biliary sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Diagnosis of decompensated chronic liver disease Septic shock as per sepsis 3 definition On controlled mechanical ventilation IJV accessible for ultrasound evaluation

Exclusion criteria

Exclusion criteria: ARDS Cardiac arrhythmias Central vein thrombosis Pregnancy Poor echocardiographic windows

Design outcomes

Primary

MeasureTime frame
To assess the diagnostic accuracy of internal jugular vein distensibility index in predicting volume responsiveness in patients with decompensated chronic liver disease and septic shockTimepoint: Baseline and after volume resuscitation—

Secondary

MeasureTime frame
To correlate IJV distensibility index with stroke volume changes measured using LVOT VTI after a standardized fluid challengeTimepoint: Baseline & after fluid challenge;To determine the optimal cut off value of IJV distensibility index for predicting fluid responsivenessTimepoint: baseline & after fluid challenge;To assess the influence of ventilation settings on IJV DI performanceTimepoint: baseline;To assess the influence of intra abdominal pressure grade on predictive performance of IJV DITimepoint: baseline;To evaluate clinical associations of baseline IJV DI & responder status with vasopressor free days at 7 days ICU & hospital length of stay need for RRT & 28day mortalityTimepoint: baseline 7 days 28 days;to assess feasibility metrics including proportion of patients with adequate IJV imaging & average time required for IJV assessmentTimepoint: at the end of study;to determine the relationship between baseline IJV distensibility index & lactate clearance in the first 6 hours after resuscitationTimepoint: baseline & 6 hours—

Countries

India

Contacts

Public ContactDr Swathi M R

Institute of liver and biliary sciences

swathimr777@gmail.com9611889494

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026