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This study compares two medicines, ketamine and etomidate, used during emergency treatment in patients with very low blood pressure (shock). It will see how each medicine affects blood pressure and heart function to find which is safer and more effective.

This study compares the effects of ketamine and etomidate on blood pressure and heart function during anesthesia induction in patients with decompensated shock. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/099463
Enrollment
79
Registered
2025-12-19
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: ketamine induction: Drug Ketamine hydrochloride administered intravenously as a single bolus dose of 1.0 mg/kg. The total duration of this intervention is a single administration at t

Sponsors

VMMC and Safdarjung Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient more than 18 years undergoing emergency induction for intubation in emergency department Systolic blood pressure less than 90 mmhg

Exclusion criteria

Exclusion criteria: patient with known allergy to ketamine and etomidate Patient presenting as already intubated

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the changes in systolic blood pressure and heart rate before and after induction with ketamine versus etomidate in decompensated shock patientsTimepoint: Time points in minutes - 0,5,10,15,30,45,60—

Secondary

MeasureTime frame
To compare the need of additional vasopressor or change in the dose of existing vasopressor of ketamine group with etomidate groupTimepoint: Additional vasopressors required or not in the 1st 1 hour after induction—

Countries

India

Contacts

Public ContactDr Dhruva Yadiyal

VMMC and Safdarjung Hospital

yadiyal.dhruva10@gmail.com8310395725

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026