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Does adding ozone to platelet therapy give better relief in knee arthritis

Effectiveness of ultrasound guided intra-articular injection of platelet rich plasma with ozone in comparison with platelet rich plasma in improving knee function and quality of life in patients with osteoarthritis of the knee: A randomized controlled trial - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/099447
Enrollment
64
Registered
2025-12-18
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Platelet rich plasma with ozone: Platelet rich plasma(4ml) with ozone(10ml) will be given intra-articularly. Passive flexion-extension movement of the knee will be done to distribute oz

Sponsors

Dr Songku Manyu
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Person with knee osteoarthritis as per 2016 revised ACR criteria for early diagnosis of osteoarthritis Age group 40-70 years Duration of symptoms more than e months Knee OA graded 2 to 3 according to KL grading Willingness to participate in the study and comply with treatment and follow up

Exclusion criteria

Exclusion criteria: Bleeding disorder Local or systemic infections Trauma Uncontrolled diabetes and hypertension/ systemic disease Recent myocardial infarction or stroke Intra-articular steroid injection during 3 months Ongoing pregnancy

Design outcomes

Primary

MeasureTime frame
WOMAC indexTimepoint: Baseline, 1week, 4week, 12week, 24week—

Secondary

MeasureTime frame
SF-36 health survey instrumentTimepoint: Baseline, 1week, 4week, 12week, 24week—

Countries

India

Contacts

Public ContactLongjam Nilachandra Singh

Regional Institute of Medical Sciences

drnilalong@gmail.com7005019045

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026