Health Condition 1: J22- Unspecified acute lower respiratory infection Health Condition 2: J159- Unspecified bacterial pneumonia Health Condition 3: J12- Viral pneumonia, not elsewhere classified
Conditions
Interventions
Intervention1: Procalcitonon based intervention to guide antibiotics therapyacute lower respiratory tract infection in pediatric population.: Use of procalcitonon values to initiate , continue , disco
Sponsors
Depatment of pediatrics ,Government multispeciality Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Children aged 2 months to 5 years with clinical diagnosis of lower respiratory tract infection like pneumonia , bronchitis , bronchiolitis with or without radiological confirmation and with informed consent from parents or guardians.
Exclusion criteria
Exclusion criteria: The exclusion criteria included neonates, children with known immunodeficiency conditions such as HIV infection, malignancy, post-transplant status, or primary immunodeficiency disorders. Children with chronic lung diseases including cystic fibrosis and bronchiectasis were also excluded. Patients presenting with severe sepsis, empyema, pleural effusion, or those requiring ICU admission at presentation were not included. Additionally, children who had received antibiotics within the previous seven days or whose parents or guardians refused consent or withdrew consent were excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To decide on the duration of antibiotic therapy based on Procalcitonin values.Timepoint: On the day of completion of antibiotic course based Procalcitonin values which are to be measured at admission and subsequently at 48 hour interval until below the cut off value. | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the rate of antibiotic initiation based on Procalcitonin based therapy.Timepoint: At the time of initial clinical assessment or hospital admission.;To compare the length of hospital stay between the Procalcitonin guided group and the standard care group.Timepoint: At hospital discharge;To evaluate the incidence of antibiotic associated adverse effects in both groups.Timepoint: Throughout hospitalization and at discharge or within seven days of discharge.;To assess clinical outcomes including treatment failure, relapse, ICU transfer, and mortality.Timepoint: During hospital stay and up to 7 days post discharge. | — |
Countries
India
Contacts
Public ContactDr Shashikiran Singh
Government Multispeciality Hospital
Outcome results
None listed