Testing two antibiotic approaches to prevent early infection after total hip replacement in patients with sickle cell anaemia

Relative risk of periprosthetic joint infection between day 1 and 3 antibiotic prophylaxis in sickle cell anaemia patients undergoing total hip arthroplasty: A non-inferiority Design randomized controlled study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099376

Enrollment

182

Registered

2025-12-18

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D578- Other sickle-cell disorders

Interventions

Intervention1: 1-Day Antibiotic Prophylaxis: Patients will receive cefuroxime 1.5 g IV within 60 minutes before surgery, with intra-operative redosing if surgery exceeds 2.5 hours, followed by two pos

Eligibility

Inclusion criteria

Inclusion criteria: Patients with sickle cell arthropathy of hip undergoing Total hip arthroplasty in the Department of Orthopaedics, AIIMS Raipur

Exclusion criteria

Exclusion criteria: 1. Patients with uncontrolled Diabetes/ malignancies / those upon immunosuppressant drugs/ etc all immunocompromised states 2. Patients with cephalosporin allergy 3. Patients with associated chronic renal disease/ chronic liver disease/ malnourished patients 4. Patients undergoing revision THA 5. Patients who had undergone any other hip surgery in the same side

Design outcomes

Primary

Measure	Time frame
The primary outcome of this study is the incidence of periprosthetic joint infection (PJI), defined according to the Musculoskeletal Infection Society (MSIS) criteria, The incidence of PJI in both the 1-day and 3-day antibiotic groups will be compared using a chi-square test. Relative risk (RR) and 95% confidence intervals (CI) will be calculated to estimate the effect size between the two treatment groups.Timepoint: 4 weeks	—

Measure

Time frame

The primary outcome of this study is the incidence of periprosthetic joint infection (PJI), defined according to the Musculoskeletal Infection Society (MSIS) criteria, The incidence of PJI in both the 1-day and 3-day antibiotic groups will be compared using a chi-square test. Relative risk (RR) and 95% confidence intervals (CI) will be calculated to estimate the effect size between the two treatment groups.Timepoint: 4 weeks

—

Secondary

Measure	Time frame
nilTimepoint: nil	—

Countries

India

Contacts

Public ContactSandeep Kumar Nema

AIIMS Raipur

drsandeepnema@gmail.com8940162132

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026