Which root canal irrigant works better - Plantaricin-149 or Chlorhexidine? A study on pain and infection

The effect of antimicrobial peptide plantaricin-149 in comparison with chlorhexidine as final root canal irrigant on the reduction of microbial load and postoperative pain in root canals with necrotic pulp - a randomised controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099370

Enrollment

Registered

2025-12-18

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Peptide Plantaricin-149: 0.013% Plantaricin-149 antimicrobial peptide will be used as final irrigant Control Intervention1: Chlorhexidine: 2% Chlorhexidine will be used as final irrigan

Eligibility

Inclusion criteria

Inclusion criteria: 1. Single rooted tooth 2. Presence of one root canal 3. Patients whose teeth have pulp necrosis, which will be confirmed by absence of a response to pulp sensitivity tests and radiographic evidence of apical periodontitis or periapical radiolucency. 4. Age of the patients:18 35 years old 5. No spontaneous pre-treatment pain or at the time of the appointment.

Exclusion criteria

Exclusion criteria: 1. Root canal treated teeth 2. Patients who used antibiotics in the past 3 months 3. Any known systemic disease 4. Teeth that could not be properly isolated 5. Advanced Periodontal disease 6. Incomplete root formation

Design outcomes

Primary

Measure	Time frame
Microbial load reductionTimepoint: S1-After access opening and before cleaning and shaping S2-After irrigation with sodium hypochlorite and EDTA S3- After final irrigation	—

Secondary

Measure	Time frame
Postoperative pain evaluationTimepoint: After 24 hours, 48 hours and 7th day	—

Countries

India

Contacts

Public ContactDr Nibedita Sahoo

S.C.B Dental College and Hospital, Cuttack

drrashmiendo1980@gmail.com8895708553

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026