A Clinical Study to Evaluate Tooth Colour Improvement Using Three Bleaching Methods in Adults With Moderate Dental Fluorosis

Clinical Efficacy of 17% Hydrogen Peroxide alone or in Combination with Cobalt-Tetraphenylporphyrin Complex, Functionalized with Reduced Graphene Oxide for Bleaching in Adults with Moderate Fluorosis - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099303

Enrollment

Registered

2025-12-17

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R688- Other general symptoms and signs Health Condition 2: K037- Posteruptive color changes of dental hard tissues

Interventions

Intervention1: Nil: Nil Intervention2: 17 percent hydrogen peroxide combined with cobalt-tetraphenylporphyrin complex: Agent to be applied on anterior teeth followed by light activation for 3 cycles.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients between age group of 18-40 years. 2. Patients with moderate fluorosis in anterior teeth score 3, classified according to the Dean Fluorosis Index- Modified (1942). 3. Tooth should have enough tooth structure for rubber dam placement.

Exclusion criteria

Exclusion criteria: 1. Patient with history of allergy toward any dental material. 2. Patient with fractured maxillary central or lateral incisors. 3. Patients with Class V carious lesions, smoking habit, pregnant, or lactating woman.

Design outcomes

Primary

Measure	Time frame
To assess the clinical efficacy of 17% hydrogen peroxide as a bleaching agent in adults presenting with moderate fluorosis stains.Timepoint: immediately after treatment, 24-hour, 72-hour and 1 week	—

Secondary

Measure	Time frame
To determine the clinical efficacy of 17% hydrogen peroxide combined with cobalt-tetraphenylporphyrin complex for bleaching in adults with moderate fluorosis stainsTimepoint: immediately after treatment, 24-hour, 72-hour and 1 week;To evaluate the clinical efficacy of 17% Hydrogen Peroxide combined with Cobalt- Tetraphenylporphyrin Complex, functionalized with Reduced Graphene Oxide for bleaching in adults with moderate fluorosis stainsTimepoint: immediately after treatment, 24-hour, 72-hour and 1 week;To compare and identify the most effective bleaching agent for treating moderate fluorosis stains in adults.Timepoint: immediately after treatment, 24-hour, 72-hour and 1 week	—

Measure

Time frame

To determine the clinical efficacy of 17% hydrogen peroxide combined with cobalt-tetraphenylporphyrin complex for bleaching in adults with moderate fluorosis stainsTimepoint: immediately after treatment, 24-hour, 72-hour and 1 week;To evaluate the clinical efficacy of 17% Hydrogen Peroxide combined with Cobalt- Tetraphenylporphyrin Complex, functionalized with Reduced Graphene Oxide for bleaching in adults with moderate fluorosis stainsTimepoint: immediately after treatment, 24-hour, 72-hour and 1 week;To compare and identify the most effective bleaching agent for treating moderate fluorosis stains in adults.Timepoint: immediately after treatment, 24-hour, 72-hour and 1 week

—

Countries

India

Contacts

Public ContactDr Vishakha GIrdhar

Shree Guru Govind Singh Tricentenary University

ashtha.arya@sgtuniversity.org9810761757

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026