A Study Comparing Three Drugs Intravenous Lignocaine Versus Labetalol Versus EsmololOn Heart Rate And Blood Pressure During Intubation In Surgery.

A Randomised Comparative Study To Compare Efficacy Of Intravenous Lignocaine Versus Labetalol Versus Esmolol For Attenuating The Haemodynamic Response To Laryngoscopy And Endotracheal Intubation At S.M.S Medical College Jaipur. - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099296

Enrollment

153

Registered

2025-12-17

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: PCS-

Interventions

Intervention1: Injection Lignocaine: Patient will receive intravenous inj lignocaine 1mg/kg diluted to 10ml with 0.9% saline 5 minutes before intubation over 60 seconds. Control Intervention1: Injecti

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient who will give written informed consent. 2. Scheduled for urgent or elective procedures requiring endotracheal anaesthesia. 3. Classified as American Society of Anaesthesiologists (ASA) physiccal status I to II. 4. Patients age between 18 and 60 years

Exclusion criteria

Exclusion criteria: 1.Any contraindication or history of hypersensitivity to study drugs. 2. Presence of atrioventricular block of any degree. 3. History of cardiac arrhythmias or heart failure. 4. presence of kidney disease. 5. Body mass index(BMI)more than 25kgm2 6.Mallampatti grade 3 and 4 7. Patient should not be a part of any other study.

Design outcomes

Primary

Measure	Time frame
To assess and compare the effect of intravenous lignocaine verus labetalol versus esmolol on haemodynamic parameters (HR,SBP,DBP,MAP) to laryngoscopy and endotracheal intubation.Timepoint: At 0,1,5 and 10 minutes after intubation.	—

Secondary

Measure	Time frame
To assess and compare proportion of patients developing any side effects.(Hypotension,Bradycardia,others)Timepoint: At 0,1,5 and 10 minutes after intubation	—

Countries

India

Contacts

Public ContactDr Sunil Chauhan

SMS Medical College Jaipur

tanyadahiya7@gmail.com9996218982

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026