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Effect of Phala Ghrita on Sperm Health and Fertility in Healthy Men and Experimental Rats

Protective effect of phala ghrita on sperm DNA integrity along with mechanistic insights on oxidative stress and spermatogenesis in Wistar rats and evaluation of its clinical effectiveness in healthy male volunteers - a pilot study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/099272
Enrollment
10
Registered
2025-12-16
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

All India Institute of Ayurveda
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Residing in Delhi or NCR for greater than 1 year with DFI greater than 15 percent. 2. Willing to provide semen samples before and after intervention. 3. Not on any fertility enhancing therapy or antioxidant supplements

Exclusion criteria

Exclusion criteria: 1. Known cases of infertility, varicocele, urogenital disease. 2. Alcoholism, smoking or drug addiction 3. Sufffering with any chronic illness (CKD, HIV, CLD etc) 4. Allergic to ghee or phala ghrita contents.

Design outcomes

Primary

MeasureTime frame
Significantly reduce sperm DNA fragmentation index (SDFI) in men living in polluted environmentsTimepoint: Outcomes will be assessed at baseline and after 90 days—

Secondary

MeasureTime frame
1.Improve semen parameters such as count, motility, & morphology. 2.Show good tolerability & no adverse effects, supporting its safety profile. 3. Provide preliminary clinical evidence for Phala Ghrita as a potential adjunct for managing pollution-induced infertility Timepoint: Outcomes will be assessed at baseline & after 90 days—

Countries

India

Contacts

Public ContactDr Ahmad Arshadullah

All India Institute of Ayurveda, New Delhi

dr.vghuddar@aiia.gov.in9986697942

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026