Comparison of Spo2/Fio2 and PaO2/FiO2 in ARDS patients

Comparison of Spo2/Fio2 ratio and Pao2/Fio2 ratio in ARDS patients - NIL

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099268

Enrollment

Registered

2025-12-16

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J80- Acute respiratory distress syndrome

Interventions

Intervention1: Arterial blood gas analysiS to get PaO2 and then calculate PaO2/FiO2 ratio: Arterial blood gas analysiS to get PaO2 and then calculate PaO2/FiO2 ratio Intervention2: Nil: Nil

Eligibility

Inclusion criteria

Inclusion criteria: Patients over 18 years of age. Diagnosis of ARDS based on Berlin Criteria. Mild ARDS PaO2 FiO2 ratio 200 mmHg and 300 mmHg with PEEP 5 cm H2O. Moderate ARDS PaO2 FiO2 ratio 100 mmHg and 200 mmHg with PEEP 5 cm H2O. Severe ARDS PaO2 FiO2 ratio 100 mmHg with PEEP 5 cm H2O. Bilateral patchy diffuse or homogeneous infiltrates consistent with pulmonary edema. Presenting with acute hypoxemia and no clinical evidence of congestive heart failure.

Exclusion criteria

Exclusion criteria: 1. Pregnant Women 2. Children 3. peripheral Vascular disease, jaundice, Inadequate SpO2 tracing

Design outcomes

Primary

Measure	Time frame
Correlation coefficient between SpO2 FiO2 and PaO2 FiO2 ratios for ARDS severity subgroups mild moderate severe. Diagnostic accuracy of SpO2 FiO2 for classifying ARDS severity compared to standard PaO2 FiO2 criteria overall accuracy sensitivity specificity.Timepoint: BASELINE, i.e., i will calculate pao2/fio2 ratio and spo2/fio2 ratio at the same time immediately on patient admission	—

Secondary

Measure	Time frame
Threshold determination Identification of SpO2 FiO2 cut-offs corresponding to established PaO2 FiO2 ARDS severity categories. Prognostic value Predictive value of SpO2 FiO2 ratio for patient-centered outcomes such as in-hospital mortality duration of mechanical ventilation ICU length of stay and development of ARDS among at-risk patients. Evaluation of reduction in arterial blood gas sampling and safety profile when using SpO2 FiO2 for monitoring.Timepoint: Nil	—

Measure

Time frame

Threshold determination Identification of SpO2 FiO2 cut-offs corresponding to established PaO2 FiO2 ARDS severity categories. Prognostic value Predictive value of SpO2 FiO2 ratio for patient-centered outcomes such as in-hospital mortality duration of mechanical ventilation ICU length of stay and development of ARDS among at-risk patients. Evaluation of reduction in arterial blood gas sampling and safety profile when using SpO2 FiO2 for monitoring.Timepoint: Nil

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Countries

India

Contacts

Public ContactDr Nadigadda Venkata Sai Sunil

Grant Medical Foundation Ruby Hall Clinic

sunilnadigadda@gmail.com9959143434

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026