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Comparison of the drugs (amisulpride and palonosetron) for prevention of nausea and vomiting in patients for removal of uterus

Antiemetic efficacy of prophylactic amisulpride versus palonosetron in patients undergoing Total Laparoscopic Hysterectomy: A randomized, double-blinded trial - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/099205
Enrollment
140
Registered
2025-12-16
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N72- Inflammatory disease of cervix uteri

Interventions

Intervention1: Amisulpride: Group A: Amisulpride 10 mg intravenously over a period of 1 minute after induction of general anaesthesia for prevention of postoperative nausea and vomiting in patients un

Sponsors

Sir Sunderlal Hospital, IMS, BHU
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Female patients aged between 40-60 years 2) ASA PS I and II 3) Patients scheduled for total laparoscopic hysterectomy

Exclusion criteria

Exclusion criteria: 1) Patients having history of CAD, COPD, DM 2) Patients in which laparoscopic surgery gets converted to open surgery 3) Patients requiring postoperative ventilation

Design outcomes

Primary

MeasureTime frame
comparison of antiemetic efficacy of amisulpride with that of palonosetron in the prevention of PONVTimepoint: The participants will be watch for symptoms like nausea and/or vomiting after the completion of surgery in the post-operative period at 0(baseline),1,2,3,4,5,6,9,12,15,18,24,30,36,42,48 hours—

Secondary

MeasureTime frame
1) Requirement of rescue antiemetic 2) Effect of duration of surgery on PONVTimepoint: 0,1,2,3,4,5,6,12,18,24,30,36,42,48 hours after surgery—

Countries

India

Contacts

Public ContactDr Anand Soliya

IMS BHU

anandsoliya78@gmail.com7987369345

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026