Health Condition 1: F102- Alcohol dependence
Conditions
Interventions
Intervention1: Thiamine: For the intervention group,
Injection thiamine will be given as per the dosage of 1000mg twice daily at 8am and 4pm respectively for first five days of the study.
Thiamine w
Sponsors
Central Institute of Psychiatry, Ranchi
Eligibility
Inclusion criteria
Inclusion criteria: Patients diagnosed with Alcohol Dependence Syndrome as per International Classification of Disease 10th revision Patients with Severity of Alcohol Dependence Questionnaire (SADQ) greater than 16 Patients with Clinical Institute Withdrawal Assessment for Alcohol (revised version) (CIWA-Ar) less than or equal to 7 Patients will be screened for cognitive deficit with Montreal Cognitive Assessment Test (MoCA), with score between 18 to 25 Patients with Beck Depression Inventory score less than or equal to 9 Patient who is ready to give informed consent.
Exclusion criteria
Exclusion criteria: Patients with history of significant head injury. Patients having any other co-morbid substance dependence. Patients with clinically diagnosed intellectual disability, autism spectrum disorder. Patients having condition accompanied by impaired cognitive functioning or specific psychiatric conditions Patients with any medical or surgical illness that interferes with the absorption and metabolism of thiamine Patients on any drugs that interferes with the absorption and metabolism of thiamine Patients who have received any form of thiamine within the last 4 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Significant effect of high dose thiamine (i.e.2000mg) on blood levels of thiamine pyrophosphate and cognitive function.Timepoint: 2 weeks and 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Significant correlation exists between baseline level of thiamine pyrophosphate in blood & cognitive function of experimental group & treatment as usual group. significant correlation between thiamine pyrophosphate & cognitive function in both groups at 2 weeks & 4 weeks.Timepoint: Baseline, 2 weeks & 4 weeks | — |
Countries
India
Contacts
Public ContactSunilkumar R Suryavanshi
Central Institute of Psychiatry, Ranchi, Kanke, Ranchi, Jharkhand
Outcome results
None listed