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Comparison of antimicrobial efficacy of different intracanal medicaments used against E. Faecalis among permanent anterior tooth

Comparative Evaluation of Antimicrobial Efficacy of Bioceramic-Based Intracanal Medicament, Calcium Hydroxide with Iodoform Paste, and Probiotic Paste with Saline Against E. faecalis in Permanent Anterior Teeth: A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/099164
Enrollment
36
Registered
2025-12-16
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Bioceramic based Intracanal Medicament: A new material as intracanal medicament, Post-BMP, a second sample will be taken and the intracanal medicament will be placed in the canal for 7

Sponsors

DR JYOTSNA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Subjects who give verbal assent and whose parents will give the informed consent. Anterior permanent teeth with traumatic or carious lesions with exposure of pulp. Teeth with minimal periapical changes with sufficient bone support. Teeth that can be restored. Subjects who had not taken any antibiotics since 3 months preceding the treatment will be incorporated in the study.

Exclusion criteria

Exclusion criteria: Presence of signs such as prolonged or spontaneous pain, pathological mobility (Miller s Grade II or more), sensitivity to percussion. The medically compromised patients and patients who had taken antibiotics within three months or require antibiotic during treatment. Non restorable tooth / Perforation of pulpal floor. Radiographic signs of internal/external root resorption. Previously endodontically treated teeth. Uncooperative children

Design outcomes

Primary

MeasureTime frame
Difference in Microbial Count of E.Faecalis after access opening and after BMPTimepoint: Difference in microbial count of E. faecalis after access opening and after biomechanical preparation (BMP). The first sample will be collected immediately after access opening, and the second sample will be collected on the same day following completion of BMP.

Secondary

MeasureTime frame
Decrease in E. Faecalis CountTimepoint: Decrease in E. faecalis Count After 1-Week Placement of Intracanal Medicaments Bioceramic-Based Intracanal Medicament, Calcium Hydroxide with Iodoform Paste & Probiotic Paste with Saline. Post-BMP, the intracanal medicament will be placed in the root canal & maintained for a period of 7 days. After 7 days, the intracanal medicament will be removed & a microbiological sample will be collected for evaluation.

Countries

India

Contacts

Public ContactDR NEHA SHEORAN

Sudha Rustagi College of Dental Sciences and Research

sheoran.neha@yahoo.co.in09711544829

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026