Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Remote ischemic preconditioning group: Remote ischemic preconditioning (RIPC) will be given by inflating an upper extremity blood-pressure cuff for 4 x 5 min to 20 mmHg above the systol
Sponsors
AIIMS Nagpur
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age more than or equal to 18 years 2. American society of anesthesiologists (ASA ) grade I or II 3. Patients with suspected primary (glioma) or metastatic brain tumor planned for elective craniotomy
Exclusion criteria
Exclusion criteria: 1. Known peripheral vascular disease 2. History of limb neuropathy, vascular surgery, deep vein thrombosis (DVT) 3. Any orthopaedic, surgical or soft tissue injury of upper limb 4. Pregnancy 5. Systolic blood pressure (SBP) more than 200 mmHg 6. Ankle brachial index less than 0.9
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Serum biomarker levels - S100beta, NSE 2. Incidence of new cerebral ischemic lesions seen on MRITimepoint: 1. Serum biomarker levels - measured before the initiation of RIPC (baseline) and at 5th postoperative day 2. Incidence of new cerebral ischemic lesions seen on MRI- within 72 hours after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital length of stay & ICU length of stay mRS Mortality within 30 days of admission Safety and feasibility of RIPCTimepoint: Hospital length of stay & ICU length of stay- at discharge from hospital mRS recorded at the time of admission, discharge from hospital, 1 month and 6 months Mortality within 30 days of admission- at 30 days postoperative Safety and feasibility of RIPC- at discharge from hospital | — |
Countries
India
Contacts
Public ContactDr Chayanika Kutum
AIIMS Nagpur
Outcome results
None listed