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Using fractional carbon dioxide laser in combination with either self-platelet rich plasma versus exosomes to treat acne scars in an individual(S)

Comparison of fractional carbon dioxide laser with autologous platelet rich plasma application versus fractional carbon dioxide laser with exosomes application in management of atrophic post acne scars a split face study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/099153
Enrollment
20
Registered
2025-12-15
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: FrCO2 + exosome: Face will then be irradiated with FrCO2 FUTURA RF- 50 model number 0121089. The treatment parameters were power-16 22 W
Duration 1ms
spacing 0.8 to 1mm and stack level 1 in each session. will undergo administration of Exosomes-0.5 ml. Control Intervention1: FrCO2 + PRP: Face will then be irradiated with FrCO2 FUTURA RF- 50 model
spacing 0.8 to 1mm and stack level 1 in each session. will undergo Autologous PRP application under sterile conditions, with1-2 mL of autologous PRP.

Sponsors

MADADI PRGNYA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients (18-65 years old) Diagnosed with atrophic acne scars Associated pigmentation Fitzpatrick skin types I-IV Able to provide informed consent

Exclusion criteria

Exclusion criteria: Active skin infections or open wounds on the face History of autoimmune disease or significant dermatologic conditions Pregnant or breastfeeding women Patients who have previously undergone CO2 laser treatment within the past 3 months History of Keloid tendency Allergy to any treatment components (exosomes, PRP, etc.)

Design outcomes

Primary

MeasureTime frame
Goodman and Baron qualitative and quantitative scores will be used to assess the improvement in Acne scar during and post treatment. Skin Texture Improvement will be assessed using Dermatologist Visual Scoring, Evaluating the improvement in skin texture, including smoothness, clarity, and overall appearance. Reduction in pigmentation is measured by pigmentation index score. Over all skin improvement is assessed based on patient experience of improvement Adverse events will be documented with its downtime with each procedure and side Timepoint: During Treatment: Monthly sessions of exosome/PRP with CO2 laser for 3 months Post-Treatment: 1-month post-treatment: Follow-up visit and evaluation 3 months post-treatment: Final assessment Final picture comparisons with pre-treatment documentation both sides separately—

Secondary

MeasureTime frame
Patient satisfaction is assessed using a patient satisfaction scale. Timepoint: Follow-up visit and evaluation 3 months post-treatment: Final assessment—

Countries

India

Contacts

Public ContactMADADI PRAGNYA

KANACHUR INSTITUTE OF MEDICAL SCIENCES

pragnyachaitanya170822@gmail.com7989692168

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026