FindTrial
Sign In

Comparing Ivabradine and Placebo to Reduce Stress During Intubation in Patients with Controlled High Blood Pressure

To compare the efficacy of oral ivabradine vs placebo in attenuating sympathomimetic response to laryngoscopy and intubation in controlled hypertensive surgical patients under general anaesthesia - Nil

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/099078
Enrollment
60
Registered
2025-12-15
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Laryngoscopy: Study drug will be given one hour prior to surgery in controlled hypertensive patients to assess its effect on laryngoscopy and endotracheal oral intubation. Control Inter

Sponsors

Sri Guru Ram Das Institute of Medical Sciences and Research, Sri Amritsar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA II & III 2.Controlled Hypertension 3.Elective surgery under general anaesthesia

Exclusion criteria

Exclusion criteria: 1.Patients on beta-blocker 2.Patients with arrhythmia 3.Cardiac/neuro surgery 4.Contraindications to ivabradine use (conduction abnormalities, AV blocks, sinoatrialblock)

Design outcomes

Primary

MeasureTime frame
To compare Heart Rate, Blood Pressure & Rate pressure product in the study group vs placebo group in controlled hypertensive surgical patients post laryngoscopy and intubationTimepoint: Heart Rate, Blood Pressure & Rate pressure product will be monitored every two minutes till 10 minute and every 5 min. till the end of surgery—

Secondary

MeasureTime frame
Side effects occurring after study periodTimepoint: monitored for 4,8,12 & 24 hours postoperatively.—

Countries

India

Contacts

Public ContactDr Parneet Kaur

Sri Guru Ram Das Institute of Medical Sciences and Research

drgaganjot@yahoo.com8198014504

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026