Preventing Low Blood Pressure After Spinal Anaesthesia: A Study Comparing IV Fluid Preloading and Phenylephrine in Females undergoing Caesarean Section.

Comparison Between Crystalloids Preload Volume and Phenylephrine Infusion to Prevent Post-Spinal Anaesthesia Hypotension in Elective Lower Segment Caesarean Section (LSCS) - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099075

Enrollment

100

Registered

2025-12-15

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O746- Other complications of spinal andepidural anesthesia during labor and delivery

Interventions

Intervention1: Phenylephrine: Patients will receive prophylactic phenylephrine infusion (0.5 microgram per kg per min) which will be started just before spinal anaesthesia and continued till the end o

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy patients (ASA II) 2. Singleton pregnancy at term (more then 36 weeks gestation). 3. Scheduled for elective LSCS under spinal anaesthesia. 4. Written informed consent. 5. Body Mass Index (BMI) between 18.5 and 29.9 kg per m 6. Height of patient is between 150 cm to 170 cm.

Exclusion criteria

Exclusion criteria: 1. High-risk pregnancies (e.g., preeclampsia, fetal distress, multiple gestation, uncontrolled diabetes ,uncontrolled hypertension, ischaemic heart disease, recent myocardial infarction, heart block, impaired renal functions and severe liver disease). 2. Contraindications to spinal anaesthesia (e.g., coagulopathy, infection at injection site, Kyphoscoliosis, Scoliosis, impaired coagulation profile, etc). 3. Pre-existing hypertension, cardiovascular disease, or diabetes. 4. Known allergy to phenylephrine or crystalloids

Design outcomes

Primary

Measure	Time frame
To evaluate the incidence of hypotension (defined as systolic blood pressure of less than 100 mmhg or a mean arterial pressure of less than 65 mmhg) in patients receiving either crystalloid preload or phenylephrine infusion during elective LSCS under spinal anaesthesiaTimepoint: Every 1 min for the first 5 min, Every 5 min till 1 hour then every 15 min till end of surgery.	—

Secondary

Measure	Time frame
To assess the incidence of maternal side effects (nausea, vomiting, bradycardia, hypertension)Timepoint: Intraoperative;To evaluate neonatal outcomes using Apgar scoresTimepoint: 1 & 5 minutes	—

Countries

India

Contacts

Public ContactDr Parmjit Singh

Government Multi Specialty Hospital

drdeepakberry@yahoo.com9872867980

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026