Health Condition 1: F112- Opioid dependence
Conditions
Interventions
Intervention1: Intervention with Sublingual Tablet in both treatment arms.: Buprenorphine is the standard treatment modality for opioid induced withdrawal. Selection criteria mandates dosage upto 8mg
Sponsors
All India Institute Of Medical Sciences Jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: Patients using natural opioids and having Opioid dependence according to ICD-11. Patient choosing withdrawal management followed by long-term antagonist management. Able to understand Hindi or English. Those who consented and are willing to attend outpatient follow-ups for the study period
Exclusion criteria
Exclusion criteria: Patients opting for Opioid Substitution Therapy. Patients who are consuming opioids other than natural opioids. Patients who will require more than 8mg of Buprenorphine to manage withdrawal. Patients with other substance dependence excluding tobacco. Patients with comorbid psychiatric illness. Patients with any chronic medical or surgical comorbidity. Patient having other pain causing illnesses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 4-week taper group is hypothesized to show better opioid abstinence and higher treatment adherence post-taper compared to the 2-week group.Timepoint: Measured at end of 5 weeks in both treatment arms | — |
Secondary
| Measure | Time frame |
|---|---|
| Improved treatment retention as measured by intention-to-treat (the number of participants still in treatment at the end of the study)Timepoint: in 5 weeks;Greater patient satisfaction post-treatment in longer taper groupTimepoint: At end of 3 & 5 week in respective arms;Differences in relapse rates or self-reported substance use between groupTimepoint: At end of study, in 5 week in both arms;Lower need for adjuvant medications in the 4 week groupTimepoint: At end of the study post 5 weeks;Reduced craving as measured by TSQM toolTimepoint: At end of 3 & 5 week in respective arms | — |
Countries
India
Contacts
Public ContactIshwar Tiwari
All India Institute of Medical Sciences
Outcome results
None listed