Effects of deep rTMS as an add on therapy on Neurophysiological, Cognitive and Clinical outcomes in patients with opioid dependence

Effects of deep rTMS as an add on therapy on Neurophysiological, Cognitive and Clinical outcomes in patients with opioid dependence - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099033

Enrollment

Registered

2025-12-15

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F111- Opioid abuse

Interventions

Intervention1: Active Deep TMS: Active Deep rTMS targetting bilateral PFC and insula will be given for 5 days. (3 sessions per day) Control Intervention1: Sham TMS: Sham TMS will be given 23 patients

Eligibility

Inclusion criteria

Inclusion criteria: Opioid use disorder patients (diagnosed by DSM-V criteria) o Age: 18 45 years o Either gender o Right-handed o Normal / Corrected to normal vision o Written informed consent o Clinical Opiate Withdrawal Scale (COW) score of 0 o Education: ability to read and write

Exclusion criteria

Exclusion criteria: o History of any other psychiatric disorders o Any neurological disorders including epilepsy o Any other known systemic disorders o Presence of any metal implants in head

Design outcomes

Primary

Measure	Time frame
Craving score (using VAS scale)Timepoint: Craving score (using VAS scale)	—

Secondary

Measure	Time frame
Scales/questionnaires, EEG functional connectivity and cognitive task measures, TMS excitability measures, HRVTimepoint: Baseline (DAY 0); Post-intervention (Day5)	—

Countries

India

Contacts

Public ContactDr TN Sathyaprabha

NIMHANS

drsathyaprabha@gmail.com08026995172

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026