Health Condition 1: R799- Abnormal finding of blood chemistry, unspecified Health Condition 2: N92- Excessive, frequent and irregularmenstruation
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Sponsors
DSTFIST
Eligibility
Inclusion criteria
Inclusion criteria: Women aged eighteen to forty five years diagnosed with polycystic ovary syndrome based on modified rotterdam criteria will be included in the study. Diagnosis of polycystic ovary syndrome requires the presence of any two out of three features namely oligo ovulation or anovulation, clinical and or biochemical signs of hyperandrogenism and polycystic ovarian morphology on ultrasonography while other causes of hyperandrogenism and menstrual irregularities such as congenital adrenal hyperplasia, androgen secreting tumours and cushing syndrome will be excluded. Polycystic ovarian morphology on ultrasonography is defined as the presence of twenty or more follicles measuring two to nine millimetres in diameter in either ovary and or increased ovarian volume more than ten millilitres with hyperechogenic enlarged central stroma, these features in a single ovary is considered sufficient to confirm polycystic ovarian morphology.
Exclusion criteria
Exclusion criteria: Participants who are unwilling to participate in the study will be excluded. Women with other causes of hyperandrogenism including congenital adrenal hyperplasia, cushing syndrome, hyperprolactinemia, thyroid dysfunction, and androgen secreting tumours will be excluded. Women with type one or type two diabetes mellitus will not be included. Women who have used lipid lowering drugs, oral contraceptives, anti androgens, insulin sensitizers such as metformin, or ovulation induction agents within the last two months will be excluded. pregnant and lactating women will be excluded.. Women with acute or chronic illnesses such as infections or tumours will also be excluded. Smokers and alcohol users will not be included in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Fatty Acid Profile - Quantitative levels of individual serum fatty acids (e.g. saturated, monounsaturated, and polyunsaturated fatty acids) in different PCOS phenotypes.Timepoint: Sample will be processed in batches within 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Association between BMI & serum fatty acid profile, Prevalence of Metabolic Abnormalities in PCOS Phenotypes, Incidence of insulin resistance & dyslipidaemia among different PCOS phenotype groupsTimepoint: Samples will be processed in batches within 6 months | — |
Countries
India
Contacts
Public ContactAksharasrri
Kasturba medical college, Manipal
Outcome results
None listed