Health Condition 1: D561- Beta thalassemia
Conditions
Interventions
Intervention1: N -acetylcysteine: Intervention group will receive oral N-acetylcysteine 10 mg/kg once daily for 6 months, administered with food along with standard iron chelation therapy.
Control I
Sponsors
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Children aged 10 to 18 years diagnosed with beta thalassemia( on regular transfusion for 1 year)
Exclusion criteria
Exclusion criteria: Children with either of the following conditions will be excluded: 1.Children with documented renal and liver dysfunction/endocrine/ cardiac dysfunction 2.Receiving any supplementation (other than folic acid) within the past one month 3.Child on any cardioprotective drugs 4.Known hypersensitivity to N-acetylcysteine 5.Refusal of consent by parent/guardian
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in cardiac iron statusTimepoint: At enrollment and after 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in MIC and echo findings in relation to serum ferritin levels after 6 months of NAC supplementation. Frequency of transfusions requirements (e.g. Average pre-transfusion haemoglobin, average transfusion interval, average transfusion volume) during study period. Any adverse effects related to NAC (infections, hospitalization, worsening anaemia). Timepoint: at 0, 3 , 6 months | — |
Countries
India
Contacts
Public ContactDr Keshika
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS) Rohtak HARYANA
Outcome results
None listed