Study to test a new plant based mosquito repellent cream for protection against mosquito bites in healthy volunteers

Evaluating the effectiveness of a novel mosquito repellent cream with the tagetyes erecta, C.pulcherima and Trans Cinnamaldhyde for personal protection among adults in mappedu thiruvallur district- A Randomised control trial - nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/098973

Enrollment

Registered

2025-12-11

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Evaluating the effectiveness of Novel Mosquito repellent cream using Tagetes erecta, C pulcherima and trans cinnamaldhyde for personal protection in rural population of Trivallur distri

Eligibility

Inclusion criteria

Inclusion criteria: 18 to 60 years of aged adults

Exclusion criteria

Exclusion criteria: Children Pregnant mothers Anyone with the history of skin lesions

Design outcomes

Primary

Measure	Time frame
Complete Protection Time (CPT): Time (in minutes/hours) between application of the repellent and the first mosquito landing or probing on treated skin Landing Rate Reduction (Biting Index)Timepoint: Complete Protection Time (CPT): Time (in minutes/hours) between application of the repellent and the first mosquito landing or probing on treated skin Landing Rate Reduction (Biting Index)	—

Secondary

Measure	Time frame
Landing Rate Reduction (Biting Index) Percentage protection Species landing index Skin irritation or adverse events Acceptability Timepoint: 1. Landing Rate (Biting Index) Time points: At minutes 15, 30, and 45 of every hour after repellent application Continues until the first mosquito landing/probing occurs (CPT) or up to 12 hours maximum Recorded during each session (herbal, DEET, placebo) 2. Percentage Protection (%) Time points: Calculated hourly using landing counts Based on the same collection intervals: 15, 30, 45 min per hour Continues until CPT or up to 12 hours 3. Species-Specific Landing Count (Aedes, Culex, Anopheles) Time points: Species identification performed for each 1-minute catch At 15, 30, 45 min every hour until CPT or up to 12 hours 4. Skin Irritation / Adverse Events Time points: Before repellent application Immediately after session completion At 24 hours post-application (to check delayed reactions) 5. Acceptability (Odour, Feel, Comfort, Willingness to Reuse) Time points: Immediately after each testing session (each of the 3 crossover sessions) One short questionnaire per session	—

Measure

Time frame

Landing Rate Reduction (Biting Index) Percentage protection Species landing index Skin irritation or adverse events Acceptability Timepoint: 1. Landing Rate (Biting Index) Time points: At minutes 15, 30, and 45 of every hour after repellent application Continues until the first mosquito landing/probing occurs (CPT) or up to 12 hours maximum Recorded during each session (herbal, DEET, placebo) 2. Percentage Protection (%) Time points: Calculated hourly using landing counts Based on the same collection intervals: 15, 30, 45 min per hour Continues until CPT or up to 12 hours 3. Species-Specific Landing Count (Aedes, Culex, Anopheles) Time points: Species identification performed for each 1-minute catch At 15, 30, 45 min every hour until CPT or up to 12 hours 4. Skin Irritation / Adverse Events Time points: Before repellent application Immediately after session completion At 24 hours post-application (to check delayed reactions) 5. Acceptability (Odour, Feel, Comfort, Willingness to Reuse) Time points: Immediately after each testing session (each of the 3 crossover sessions) One short questionnaire per session

—

Countries

India

Contacts

Public ContactDr Tharani Vasudevan

Saveetha Medical College and Hospital

drgdineshkumar@gmail.com9176665439

Outcome results