Comparing antimicrobial-coated and standard central lines to reduce bloodstream infections in patients after off-pump bypass surgery

Efficacy of antimicrobial-coated central venous catheters versus standard central venous catheters in preventing central-line associated blood-stream infections in postoperative off-pump coronary artery bypass grafting patients: a randomised controlled study - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/098923

Enrollment

180

Registered

2025-12-11

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B998- Other infectious disease

Interventions

Intervention1: Antimicrobial-coated CVCs AMC CVCs: AMC-CVCs will be used in the intervention group in the operation theatre. Trained anesthesiologists will place all CVCs under strict aseptic precauti

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients who have undergone elective OPCAB and with positive blood culture after 2 calendar days of ICU admission 2. Age more than 18 years. 3. Patients who will provide written informed consent.

Exclusion criteria

Exclusion criteria: 1. History of hypersensitivity to the antimicrobial agents (polyhexamethylbiguanide PHMB) used in the coated catheters. 2. Patients requiring central venous catheterization for less than 48 hours. 3. Patients with immunocompromised states or on immunosuppressive therapy. 4. Intraoperative conversion from off-pump to on-pump coronary artery bypass grafting. 5. Use of intra-aortic balloon pump perioperatively.

Design outcomes

Primary

Measure	Time frame
To determine CLABSI Rate per 1000 central line days in post OPCAB patients with and without antimicrobial coated central venous catheters AMC CVCs versus S-CVCTimepoint: 48 hours post-randomization and 48 hours after CVC removal	—

Secondary

Measure	Time frame
To evaluate the time to the first bloodstream infection occurring between 48 hours post-randomization and 48 hours after CVC removal comparing antibiotic impregnated and standard CVCs following OPCAB surgery To Evaluate trends in inflammatory biomarkers such as WBC counts C reactive protein and procalcitonin levels To determine the length of ICU and hospital stay Timepoint: 48 hours post randomization and 48 hours after CVC removal	—

Measure

Time frame

To evaluate the time to the first bloodstream infection occurring between 48 hours post-randomization and 48 hours after CVC removal comparing antibiotic impregnated and standard CVCs following OPCAB surgery To Evaluate trends in inflammatory biomarkers such as WBC counts C reactive protein and procalcitonin levels To determine the length of ICU and hospital stay Timepoint: 48 hours post randomization and 48 hours after CVC removal

—

Countries

India

Contacts

Public ContactGegal Pruthi

AIIMS BATHINDA

drpkc12@gmail.com8558038098

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026