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Study of knee tissue removed during knee replacement surgery to detect hidden inflammatory arthritis in patients with osteoarthritis

Undiagnosed Inflammatory Arthritis in Osteoarthritis Knees Undergoing Total Knee Arthroplasty: A Prospective Clinical and Histopathological Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/12/098920
Enrollment
150
Registered
2025-12-11
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M00-M99- Diseases of the musculoskeletal system and connective tissue

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

Dr Ankush Nayyar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for primary total knee arthroplasty (TKA) for a clinical and radiological diagnosis of primary osteoarthritis of the knee. Radiographic evidence of osteoarthritis. Able and willing to provide written informed consent for collection and histopathological analysis of resected tissue. Sufficient synovial/tissue expected to be available at surgery for histopathological analysis.

Exclusion criteria

Exclusion criteria: Revision TKA or previous major ipsilateral knee arthroplasty (i.e., not a primary TKA). Active local or systemic infection (e.g., cellulitis, septic arthritis, sepsis) at time of surgery. Recent intra-articular corticosteroid injection in the index knee within 3 months prior to surgery. Ongoing systemic corticosteroid therapy or disease-modifying antirheumatic drugs (DMARDs) started for an inflammatory arthritis diagnosis within the last 6 months.

Design outcomes

Primary

MeasureTime frame
To determine the proportion of osteoarthritis knee patients undergoing total knee arthroplasty who show histopathological features of inflammatory arthritis in resected synovial/tissue specimens.Timepoint: At the time of surgery and at histopathological examination of resected tissue—

Secondary

MeasureTime frame
To characterize the specific histopathological patterns of inflammation (e.g., synovitis grade, lymphoplasmacytic infiltrate, pannus formation). (Timeframe: Postoperative histopathology reporting) To correlate histopathological findings with preoperative clinical features such as pain severity, deformity, ESR, CRP, & radiographic grade. To identify the prevalence of previously undiagnosed inflammatory arthritis among patients clinically labeled as primary osteoarthritis. To evaluate whether the presence of inflammatory pathology affects early postoperative symptoms or recovery parameters (optional only if you plan to record this).Timepoint: At the time of surgery & at histopathological examination of resected tissue—

Countries

India

Contacts

Public ContactBushu Harna

Consultant Pathology and Research and Publications Officer

ankush.nayyar@gmail.com09914599333

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026