Health Condition 1: K740- Hepatic fibrosis
Conditions
Interventions
Intervention1: Dapagliflozin, 10mg: Dose: 10mg/day.
Frequency: once a day, with or without meal.
Route of administration: oral.
Total duration of intervention: 6 months
Control Intervention1: Standa
Sponsors
Dr Surender Kumar
Eligibility
Inclusion criteria
Inclusion criteria: Liver cirrhosis patients with refractory ascites whom ascites is not recovered with best standard medical therapy and large volume paracentasis.
Exclusion criteria
Exclusion criteria: patients who have chronic kidney disease and history of infections, hypoglycemia, hyponatriemia, fractures, acute kidney injury.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Control of ascites, complete response, partial response and no response at the follow up of 6 months.Timepoint: Control of ascites, complete response, partial response and no response at the follow up of 6 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in 24hours urinary sodium ,24 hours urinary volume, EGFR, survival at six months, adverse events throught the follow up like subacute bacterial peritonitis, hypoglycemia, acute kidney injury, pneumonia.Timepoint: From taking into recruitment till 6 months of follow up after taking in the randomization arms. | — |
Countries
India
Contacts
Public ContactSurender Kumar
Department of Gastroenterology, Dr S.N. Medical College and MDM Hospital, Jodhpur, Rajasthan, India
Outcome results
None listed