Comparison of Pain-Relieving Medicines on Tooth Sensibility over Time in People with Dental Pain

Comparative Evaluation of the Analgesic Effect of various Premedications on Pulpal Sensibility Tests at Different Time Intervals in Patients with Endodontic Pain: A Clinical Trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/098787

Enrollment

120

Registered

2025-12-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A499- Bacterial infection, unspecified

Interventions

Intervention1: combination of Ibuprofen (400 mg) and Paracetamol/Acetaminophen (325 mg) (Combiflam): patient will be given this combination of medication after confirming diagnosis of SIP. Pain will t

Eligibility

Inclusion criteria

Inclusion criteria: 1. Chief complaints should include cold/hot drinks cause lingering pain. 2. Actively experiencing moderate to severe pain 3. Positive response to cold testing with Endo ice. 4. Mature permanent vital mandibular molar. Systemically healthy patients. Teeth having sufficient tooth structure for adequate isolation. No history of previous endodontic therapy. No history of trauma to the involved tooth.

Exclusion criteria

Exclusion criteria: 1. Patients who have a positive history of analgesic intake within past 3 days. 2. Patients with periapical lesion. 3. Patients who have a positive history of antibiotics intake in the last month. 4. Periodontally compromised teeth. Patients with known history of allergy to the drugs in study. Diabetic, immunocompromised patients, pregnant, lactating females. Calcified roots. Neurologic patients. Psychiatric patients who are not able to rate the pain on scale.

Design outcomes

Primary

Measure	Time frame
To assess the effect of combination of Ibuprofen (400 mg) and Paracetamol/Acetaminophen(325 mg) on Electric pulp testing and cold test Timepoint: at intervals of 20 minutes, 40 minutes,60 minutes	—

Secondary

Measure	Time frame
To assess the effect of Ketorolac tromethamine (20 mg) on Electric pulp testing and cold testTimepoint: at intervals of 20 minutes, 40 minutes,60 minutes ;To compare the effect of Ibuprofen (400 mg) and Paracetamol/Acetaminophen(325 mg), Ketorolac tromethamine(20mg) on cold test and Electric pulp testingTimepoint: at intervals of 20 minutes, 40 minutes,60 minutes;o identify an analgesic that is more effective for pain relief during diagnostic testsTimepoint: at intervals of 20 minutes, 40 minutes,60 minutes	—

Measure

Time frame

To assess the effect of Ketorolac tromethamine (20 mg) on Electric pulp testing and cold testTimepoint: at intervals of 20 minutes, 40 minutes,60 minutes ;To compare the effect of Ibuprofen (400 mg) and Paracetamol/Acetaminophen(325 mg), Ketorolac tromethamine(20mg) on cold test and Electric pulp testingTimepoint: at intervals of 20 minutes, 40 minutes,60 minutes;o identify an analgesic that is more effective for pain relief during diagnostic testsTimepoint: at intervals of 20 minutes, 40 minutes,60 minutes

—

Countries

India

Contacts

Public ContactDr Sumeet Sharma

SGT University

drsharma.endo_fdsc@sgtuniversity.org9873122335

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026