Health Condition 1: G20- Parkinsons disease
Conditions
Interventions
Intervention1: Standard Care + Vitamin B9: Standard Care (Carbidopa 25mg + Levodopa 100mg) thrice daily oral + Vitamin B9 400mcg once daily oral for 6 months
Intervention2: Standard Care + Vitamin B
Sponsors
SRM Medical College and Research centre
Eligibility
Inclusion criteria
Inclusion criteria: Cognitive impairment (MoCA score below 24)receving standard PD therapy
Exclusion criteria
Exclusion criteria: Patients with Thalassemia Individual diagnosed with G6PD deficiency or Sickle cell disease Subject with Hemochromatosis (serum ferritin more than 1000ng/ml & transferrin saturation more than 45 percent Participants presenting with severe kidney disease or advanced renal/liver impairment (eGFR less than 30 ml/min/1.73m^2 , child pugh class C) History of gastric ulcers or pernicious anemia (vit B12 less than 150pg/ml) Case of severe anemia (HB less than 7g/dl)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The outcome of this study will give a clear understanding of the cognitive enhancing abilities of vitamins (B9,B12,C&D) among Indian populationTimepoint: Biomarker assessment: Beta amyloid 40 & 42 ratio Baseline , 3rd month, 6th month | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the safety & tolerability of these vitamins by monitoring ADRs To compare the quality of life between control & treatment groups using scores & scalesTimepoint: MoCA & Neuro QoL score scale assessment: Baseline, 3rd month & 6th month | — |
Countries
India
Contacts
Public ContactDr S Robert wilson
SRM Institute of Science and Technology, Kattankulathur
Outcome results
None listed