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Which Anesthesia Sedation Helps the Brain Recover Faster? Propofol or Dexmedetomidine

Comparison of cognitive recovery using propofol or dexmedetomidine infusion on patients undergoing elective surgery under general anesthesia - Nil

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/098777
Enrollment
60
Registered
2025-12-10
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: General Anaesthesia: Induction of anaesthesia will be performed using etomidate at a dose of 0.2 to 0.5 mg/kg administered intravenously. duration of anaesthesia is induction to extubat

Sponsors

Sri Guru Ram Das Institute of Medical Sciences and Research, Sri Amritsar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA Physical Status I or II. 2. Elective non-neurological, non-cardiac surgeries lasting 1 3 hours. 3.Preoperative MoCA scores within normal limits. 4.Patients able to read, write, and understand the vernacular language Punjabi or English. 5.Patients having primary level education.

Exclusion criteria

Exclusion criteria: 1.Pre-existing cognitive dysfunction (MoCA less than 26). 2.Patient on Beta blockers 3.Low heart rate 4.History of neurological or psychiatric illness. 5.Chronic alcohol or drug abuse. 6.Hearing or visual impairments affecting test performance 7.Emergency surgeries.

Design outcomes

Primary

MeasureTime frame
To compare change in cognitive scoreTimepoint: To compare change in baseline cognitive score at 2, 6 and 24 hr

Secondary

MeasureTime frame
1.Adverse effects of drugs 2.Hemodynamic parameters: heart rate, systolic/diastolic BP.Timepoint: Continuous intraoperative, vitals such as heart rate, blood pressure, SpO2, respiratory rate will be recorded every 2min interval for first 10 min & then at 5 min interval till the end of surgery.

Countries

India

Contacts

Public ContactDr Shaina Kaur Shahi

Sri Guru Ram Das Institute of Medical Sciences and Research

chiteshwarwalia@gmail.com9878339933

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026