A study to find out whether liquid platelet rich fibrin as a carrier medium for local delivery of doxycycline into moderate periodontal pockets has an added advantage to help gums heal better after cleaning in comparison to doxycycline gel alone

Comparative evaluation of local drug delivery of doxycycline with a novel vehicle injectable-platelet rich fibrin versus doxycycline gel as an adjunct to nonsurgical periodontal therapy in periodontitis: a randomized controlled clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/098764

Enrollment

Registered

2025-12-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: doxycycline with Injectable platelet rich fibrin: Local drug delivery of doxycycline with Injectable Platelet rich fibrin as a vehicle in moderately deep periodontal pockets at 12 sites

Eligibility

Inclusion criteria

Inclusion criteria: 1.Individuals above 18 years of age. 2. A minimum of 20 natural teeth present 3.Systemically healthy patients diagnosed with periodontitis 4. Patients having pocket probing depth of 4-6 mm. Diagnosis: Stage II (Grade A, Grade B), Stage III (Grade A, Grade B) According To Classification of Periodontal Diseases 2017) 5. Only patients agreeing to give consent are included.

Exclusion criteria

Exclusion criteria: 1.Individuals using any form of alcohol and tobacco. 2.Individuals who have used antibiotics, probiotics, non-steroidal anti-inflammatory drugs and/or steroids within the past 3-months. 3.Individuals with systemic diseases. 4.Lactating and/or pregnant females.

Design outcomes

Primary

Measure	Time frame
Pocket Probing Depth Mild: 0-3mm moderate: 3-6mm Severe:more than 6mmTimepoint: Pocket Probing Depth Mild: 0-3mm moderate: 3-6mm Severe:more than 6mm	—

Secondary

Measure	Time frame
Clinical Attachment LevelsTimepoint: 6 weeks and 12 weeks	—

Countries

India

Contacts

Public ContactDr Khushee Agrawal

YOGITA DENTAL COLLEGE AND HOSPITAL

mailprs999@gmail.com9886191999

Outcome results