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A study in older adults with obesity and diabetes to see how a yoga program affects brain health and memory

An MR-neuroimaging study of structural and vascular brain networks in elderly adults with obesity and diabetes who practice structural yoga - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/098738
Enrollment
80
Registered
2025-12-10
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: Structured Yoga Module for Obese Diabetic Elderly Adults: A structured yoga module specifically developed for elderly adults with obesity and diabetes, following AYUSH guidelines and va

Sponsors

INDIAN COUNCIL OF MEDICAL RESEARCH
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adults aged 60 to 80 years. 2. Clinically diagnosed with Type 2 Diabetes Mellitus. 3. BMI greater than or equal to 25 kg/m (Asia-Pacific classification for obesity). 4. Referred for MRI and able to undergo MRI procedures. 5. Willing to participate and provide written informed consent. 6. Able to follow yoga instructions and perform basic physical movements.

Exclusion criteria

Exclusion criteria: 1. History of neurological disorders (e.g., stroke, epilepsy, brain tumors, neurodegenerative diseases). 2. Psychiatric illnesses affecting cognition (e.g., major depression, schizophrenia). 3. Severe musculoskeletal, cardiovascular, or respiratory conditions that limit physical activity or make yoga unsafe. 4. Contraindications to MRI (e.g., pacemaker, metallic implants, claustrophobia). 5. Uncontrolled hypertension or uncontrolled diabetes. 6. Current participation in structured yoga or exercise programs. 7. Any condition that, in the investigator s opinion, may interfere with participation or study outcomes.

Design outcomes

Primary

MeasureTime frame
Outcome 1: Change in carotid artery flow velocity and artery diameter measured by Doppler ultrasound. Outcome 2: Change in total and regional brain volumes measured using T1-weighted MRI (FSPGR sequence). Outcome 3: Change in white matter integrity measured using Diffusion Tensor Imaging (DTI). Outcome 4: Change in resting-state functional connectivity and BOLD signal patterns from resting-state fMRI.Timepoint: Baseline (pre-intervention) and 6 months(26 weeks) post-intervention.—

Secondary

MeasureTime frame
Outcome 1: Change in cognitive performance on the Eriksen Flanker Test (accuracy % & reaction time in milliseconds). Outcome 2: Change in working memory performance on the N-Back Test (accuracy % on 0-back, 1-back, 2-back, & 3-back tasks).Timepoint: Baseline (pre-intervention) & 6 months(26 weeks) post-intervention.—

Countries

India

Contacts

Public ContactDr Suresh Sukumar

Manipal College of Health Professions, Manipal Academy of Higher Education

suresh.sugumar@manipal.edu9886118811

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026