Jaw joint pain treatment using two different intra joint injections

Effectiveness of Injectable Platelet-Rich Fibrin (i-PRF) vs Hyaluronic Acid in the Treatment of Internal Derangement of the Temporomandibular Joint (TMJ): A MRI-Based Prospective Randomized Clinical Study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/098716

Enrollment

Registered

2025-12-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: Injectable Platelet-Rich Fibrin: Autologous blood collection 10ml and centrifugation using low-speed centrifugation protocol (e.g., 700 rpm for 3 min). Arthrocentesis as per Nitzan s te

Eligibility

Inclusion criteria

Inclusion criteria: Healthy Patients aged 18 to 50 years Diagnosed with internal derangement of TMJ Wilkes stage two to four for whom conservative management has failed Unilateral or bilateral involvement Willing to provide informed consent and attend follow up visits

Exclusion criteria

Exclusion criteria: Systemic joint diseases Other systemic diseases that can affect the joint health Previous TMJ surgery or injection TMJ ankylosis Wilkes stage one and five Pregnancy or lactation. Coagulation disorders or platelet dysfunction. Claustrophobic patients

Design outcomes

Primary

Measure	Time frame
MRI-based evaluation(both at closed and open mouth) at baseline and 3months post-injection for 1. Disc position (normalized, partially improved, unchanged, worsened). 2. Joint space (increased/reduced/normal). 3. Superior Bands of lateral pterygoid muscle position Clinical Outcome 1. Pain (VAS score 0 10) at baseline, 1 week, 1 month and 3 months. 2. Maximum mouth opening (mm). 3. Joint sounds (clicking/crepitus). Timepoint: baseline, 1 week, 1 month and 3 months.	—

Measure

Time frame

MRI-based evaluation(both at closed and open mouth) at baseline and 3months post-injection for 1. Disc position (normalized, partially improved, unchanged, worsened). 2. Joint space (increased/reduced/normal). 3. Superior Bands of lateral pterygoid muscle position Clinical Outcome 1. Pain (VAS score 0 10) at baseline, 1 week, 1 month and 3 months. 2. Maximum mouth opening (mm). 3. Joint sounds (clicking/crepitus). Timepoint: baseline, 1 week, 1 month and 3 months.

—

Secondary

Measure	Time frame
Functional limitations (chewing, yawning, speech). Patient satisfaction (Likert scale) Biochemical analysis of fluid obtained during arthrocentesis- To look for inflammatory mediators/ProteinsTimepoint: baseline, 1 week, 1 month and 3 months.	—

Countries

India

Contacts

Public ContactSatheesh G

Adhiparasakthi dental college and hospital

gsatheeshdental@gmail.com9952124010

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026