Health Condition 1: J120- Adenoviral pneumonia
Conditions
Interventions
Intervention1: Intravenous Immunoglobulin in Combination with Standard Care: Children with severe adenoviral pneumonia will be randomly assigned to receive IVIG (2g/kg over 2 days) in combination wit
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: Children (1mo-14 years) with severe pneumonia admitted to the pediatric ICU and HDU with RT-PCR positive for adenovirus.
Exclusion criteria
Exclusion criteria: 1. Patients presenting with proven bacterial pneumonia, empyema or hospital-acquired pneumonia. 2. Patients for whom the use of IVIG is contraindicated. 3. Patients who developed secondary HLH after adenoviral infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical improvement within 28 days after randomization. Clinical improvement is defined as a two-point reduction after the use of the drug in patients clinical status on a six-point ordinal scale or live discharge from the hospital, whichever comes first.Timepoint: 0, 2weeks and 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include all-cause mortality at day 28, frequency of invasive mechanical ventilation, duration of oxygen support, duration of hospitalization, & need for organ support.Timepoint: o, 2 weeks, 4 weeks | — |
Countries
India
Contacts
Public ContactBijay Kumar Meher
SVPPGIP, SCB Medical College, Cuttack
Outcome results
None listed