A study comparing intravenous clonidine and intravenous magnesium sulphate to reduce blood pressure and heart rate changes during operation

A prospective comparative study of effects of intravenous clonidine versus intravenous magnesium sulphate in attenuating hemodynamic stress responses during laryngoscopy and endotracheal intubation in spine surgeries. - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/098687

Enrollment

Registered

2025-12-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Clonidine: Injection is given 1.5 mcg/kg in 50ml NS over 20min, 10 min prior to induction Control Intervention1: Magnesium sulphate: Injection 50mg/kg given 10 min prior to induction

Eligibility

Inclusion criteria

Inclusion criteria: Patient giving consent ASA grade 1,2 Posted for elective spine surgery

Exclusion criteria

Exclusion criteria: Patient not giving consent ASA grade 3,4,5 High serum magnesium levels

Design outcomes

Primary

Measure	Time frame
To compare the effects of inj. Clonidine 1.5mcg/kg I.V Versus inj. Magnesium sulphate 50mg/kg I.V on attenuation of hemodynamic stress responses to laryngoscopy and endotracheal intubationTimepoint: 0 to 24 hours	—

Secondary

Measure	Time frame
Comparing hemodynamic stress response during laryngoscope and intubationTimepoint: 0 to 24 hours	—

Countries

India

Contacts

Public ContactDr NEVIL BALAR

Smt.Bhikiben Kanjibhai Shah Medical Institute and Research Centre

dr_jatinpatel@yahoo.co.in9879368363

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026