Comparing use of giving oxygen with minimal pressure vs high flow oxygen without pressure in improving oxygen storage in lungs before giving general anaesthesia in patients posted for laparoscopic surgeries.

Preoxygenation with Pressure Support Ventilation (PSV) mode versus high flow oxygen with Zero End Expiratory Pressure (ZEEP) on end tidal Oxygen in rapid sequence intubation (RSI). - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/098665

Enrollment

Registered

2025-12-08

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis Health Condition 2: K409- Unilateral inguinal hernia, without obstruction or gangrene

Interventions

Intervention1: Preoxygenation with Pressure Support Ventilator Mode: preoxygenation will be done in Pressure support ventilator mode with pressure support of 2 cm of H2O and PEEP of zero for three min

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 to 80 years posted for laparoscopic surgeries ASA 1 and 2

Exclusion criteria

Exclusion criteria: ASA 3 and above Patients with Respiratory Illness Edentulous Patients Pregnant patients Emergency procedures Patients with Difficult Intubation Patients with Increased Intracranial Pressure Patients with Recent Gastric Surgery Patients with Pharyngeal and Esophageal surgery Refusal by Patients

Design outcomes

Primary

Measure	Time frame
To measure the End tidal Oxygen at the end of 3 minutes of preoxygenation comparing between pressure support ventilation and high flow oxygen with zero PEEP Timepoint: To measure the End tidal Oxygen at the end of 3 minutes of preoxygenation comparing between pressure support ventilation and high flow oxygen with zero PEEP	—

Secondary

Measure	Time frame
To compare the Oxygen Saturation at the end of intubation between two techniques of Preoxygenation. Timepoint: 5 mins from the starting of preoxygenation;To compare partial pressure of oxygen between arterial (PaO2) and venous (PvO2) blood prior to oxygenationTimepoint: ;To measure PvO2 after intubationTimepoint: ;To compare the tidal volumes during preoxygenation with normal inspiratory effortTimepoint: ;To compare the End Tidal Oxygen (EtO2) at the end of intubation will be notedTimepoint:	—

Measure

Time frame

To compare the Oxygen Saturation at the end of intubation between two techniques of Preoxygenation. Timepoint: 5 mins from the starting of preoxygenation;To compare partial pressure of oxygen between arterial (PaO2) and venous (PvO2) blood prior to oxygenationTimepoint: ;To measure PvO2 after intubationTimepoint: ;To compare the tidal volumes during preoxygenation with normal inspiratory effortTimepoint: ;To compare the End Tidal Oxygen (EtO2) at the end of intubation will be notedTimepoint:

—

Countries

India

Contacts

Public ContactRahavi

Christian Medical College Vellore

tonythomson@cmcvellore.ac.in9500242412

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026