Comparison of dexamethasone and ketamine as a supplement to levobupivacaine for pain relieving nerve block technique in lower back surgery.

Efficacy of dexamethasone versus ketamine as adjuvant to 0.25 percentage Levobupivacaine in Ultrasound-guided erector spinae plane block in lumbar fusion surgery- A randomized controlled study. - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/098621

Enrollment

Registered

2025-12-08

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Addition of Dexamethasone as adjuvant to 0.25 percent of Levobupivacaine in Erector spinae block for lumbar fusion surgery: Group 1: will receive 20 ml of 0.25 percent Levobupivacaine +

Eligibility

Inclusion criteria

Inclusion criteria: 1.American Society Of Anaesthesiologists(ASA) physical status I-III. 2.Patients aged more then 30 years undergoing single level lumbar fusion surgery .

Exclusion criteria

Exclusion criteria: 1.Allergy to study drugs 2.Coagulopathy 3.Local and systemic infections. 4.Patients with cognitive impairment . 5.BMI more than or equal to 30 kg per m 6.Lumbar spine injury. 7.Significant hepatic and renal function impairment.

Design outcomes

Primary

Measure	Time frame
To compare the Visual Analog Scale(VAS) pain scores to 0,2,4,8,12,18 and 24 hours post operativelyTimepoint: 0,2,4,8,12,18 and 24 hours	—

Secondary

Measure	Time frame
1.Intraoperative- Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP) before incision, 3mins after incision and then every 15 minutes till the end of surgery, 2.Time to first rescue analgesic. 3.Total number of times of requirement of rescue analgesic. 4.Incidence of side effects like respiratory depression, sedation, nausea and vomiting. Timepoint: 1.Before incision. 2.3 mins after incision. 3.Every 15 mins after incision.	—

Measure

Time frame

1.Intraoperative- Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP) before incision, 3mins after incision and then every 15 minutes till the end of surgery, 2.Time to first rescue analgesic. 3.Total number of times of requirement of rescue analgesic. 4.Incidence of side effects like respiratory depression, sedation, nausea and vomiting. Timepoint: 1.Before incision. 2.3 mins after incision. 3.Every 15 mins after incision.

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Countries

India

Contacts

Public ContactAlisha Mohanty

Kalinga Institute Of Medical Sciences

amitpdear@gmail.com9437191002

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026