Health Condition 1: E119- Type 2 diabetes mellitus without complications
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Government Institute of Medical Sciences (GIMS)
Eligibility
Inclusion criteria
Inclusion criteria: Cases- 1.Adults aged 30 70 years 2.Diagnosed with T2DM (as per ADA criteria) 3.Diagnosed with DN all stages included according to KDIGO guidelines (based on UACR, eGFR.) 4.Consent to participate Controls- 1.Controls are above mentioned patients except for the development of DN.
Exclusion criteria
Exclusion criteria: 1.Other kidney diseases (non-diabetic nephropathy) 2.Obstructive uropathy 3.Patient on nephrotoxic drugs, Liver failure, Previous cardiovascular events, Autoimmune disorder, Acute or chronic infection or malignancy 4.Current use of immunosuppressive or anti-inflammatory therapy, Pregnant and lactating females
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To estimate the level of serum TXNIP, IL-1beta and MDA in patient of diabetes mellitus type 2 with and without nephropathy. 2. To determine the gene expression of TXNIP , IL-1beta in Diabetes Mellitus type 2 patients with and without nephropathy. 3. To assess the correlation between levels of TXNIP and , IL-1beta and its expression with parameters of renal function.Timepoint: At the Time of Enrollment only | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the correlation between levels of TXNIP , IL-1beta and Malondialdehyde (MDA) and gene expression of TXNIP and IL-1 beta .Timepoint: At the Time of Enrollment only | — |
Countries
India
Contacts
Public ContactDr Smriti
Government Institute of Medical Sciences (GIMS)
Outcome results
None listed