Health Condition 1: B749- Filariasis, unspecified
Conditions
Interventions
Intervention1: Integrative treatment: The components of integrative treatment for lymphatic filariasis are
skin wash with soap and water, phanta soaking, yoga and pranayama, Indian manual lymph drainage (IMLD) and compression therapy. The Phanta is an Ayurvedic herbal solution in which, the limb is dipped
Sponsors
Nil
Eligibility
Inclusion criteria
Inclusion criteria: Provisional Diagnosis of Lymphatic Filariasis Patients with ISL Grade 2 (Early or Late) or Grade 3 lymphoedema with brawny/organized oedema
Exclusion criteria
Exclusion criteria: Patients currently or recently have experienced an acute inflammatory episode (cellulitis/filarial fever/ADLA) during the previous month of reporting. Other causes of lymphoedema determined clinically, such as traumatic, secondary or genetic lymphoedema. Pregnancy or lactation The patients who consumed systemic corticosteroids, immunosuppressive drugs, or anti- inflammatory treatments (as a course) in the past 2 months. Patients with history of major chronic illness or communicable disease (Active cancer, Tuberculosis, Autoimmune diseases, HIV, Hepatitis B, Hepatitis C), Patients with chronic kidney disease greater than Stage 3, Patients with chronic diabetes (if RBS is greater than 300 mg/dL)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative change in collagen turnover biomarkers (MMPs, TIMPs, lysyl oxidase, hydroxyproline) in serum/plasma/urine samples before and after 14 days of Integrative Medical (IM) treatment. Identification of differentially expressed proteins through mass spectrometry that correlate with lymphoedema reversal. Correlating clinical outcomes (such as limb volume changes) with molecular and biochemical markers.Timepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Establishment of a reference proteome map for lymphoedema in Lymphatic Filariasis. Validation of candidate biomarkers using Western blotting and/or PCR from plasma samples. Assessment of biochemical parameters (e.g., liver/kidney function, lipid profile, calcium, ceruloplasmin, copper/zinc) pre- and post-treatment.Timepoint: 3 years | — |
Countries
India
Contacts
Public ContactDr. S. R. Narahari
Institute of Applied Dermatology
Outcome results
None listed