A study on changes in optic nerve diameter at different carbon dioxide levels during anaesthesia in children

Assessment of change in optic nerve sheath diameter with various end-tidal CO2 levels in anaesthetized paediatric patients using transorbital ultrasonography - Nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/098530

Enrollment

Registered

2025-12-05

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Assessment of change in optic nerve sheath diameter with various end-tidal CO2 levels in anaesthetized paediatric patients using transorbital ultrasonography: General anaesthesia will b

Eligibility

Inclusion criteria

Inclusion criteria: Paediatric patients of either sex having age group between 2-14 years belonging to ASA physical status I and II scheduled for undergoing elective surgery in supine position under general anaesthesia requiring tracheal intubation

Exclusion criteria

Exclusion criteria: Patients refusing to participate, patients with any ophthalmic disease, patients with neurological complications (abnormal raised ICP, hydrocephalus, intracranial tumors), patients with congenital heart disease, patients with respiratory disease, patients undergoing laproscopic surgeries, patients with history of any adverse reaction to ultrasound gel

Design outcomes

Primary

Measure	Time frame
To quantify the changes in optic nerve sheath diameter (ONSD) caused by controlled alterations in end-tidal CO2 levels (Etco2)Timepoint: First reading at 10 min after general anaesthsia with EtCo2 of 35 mm Hg, second at 5 min after attaining the EtCo2 level at 30 mm Hg and the third reading at 5 min after attaining EtCo2 at 35 mm Hg again. Final reading at 5 min after attaining EtCo2 at 40 mm Hg.	—

Secondary

Measure	Time frame
To measure the effect of variable levels of end-tidal CO2 on hemodynamic parameters i.e. Heart rate (HR), Mean arterial pressure (MAP) & oxygen saturation (SPO2)Timepoint: Measurement of HR, MAP & SPO2 will be recorded before induction of anaesthesia, after induction of anaesthesia, after intubation & with every ultrasound measurement at various EtCo2 levels every 5 minutes	—

Countries

India

Contacts

Public ContactDr Rozi Sharma

Pandit BD Sharma post graduate institute of medical sciences

summivashishth@gmail.com8221986262

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026