Health Condition 1: G231- Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
Conditions
Interventions
Intervention1: Transcranial Magnetic Stimulation: rTMS over left dorsolateral prefrontal cortex will be conducted using a high-frequency protocol (10 Hz), applying 60 trains of 50 pulses with a durati
Sponsors
Citi Neuro Centre Foundation
Eligibility
Inclusion criteria
Inclusion criteria: -Diagnosis of PSP according to MDS criteria -Ability to stand unassisted for 30 seconds and able to walk independently -MMSE 18 or more -On stable treatment of anticholinergic, dopaminergic, serotonergic or NMDA antagonist medication -Age 40 80 years -Able to undergo MRI and rTMS -Informed consent provided
Exclusion criteria
Exclusion criteria: -Contraindications to rTMS or MRI (e.g., metallic implants) -Pregnancy -History of cerebellar ataxia, SOL, hydrocephalus, SDH, Prior vestibular disease -Sensory deficit in feet -Epilepsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gait: Change in Time taken to walk 10 meters measured via video gait recording of Timed up and go test (TUG) Cognition: Changes in Montreal Cognitive Assessment (MoCA) and Frontal assessment battery (FAB) scoresTimepoint: 2 months, 3 months, 4 months and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| -Change in number of Falls with falls diary -Change in PSP rating scale -Changes in Brain perfusion: ASL MRI to assess regional cerebral blood flow changes in relevant cortical and subcortical regionsTimepoint: 4 months | — |
Countries
India
Contacts
Public ContactDr Yaranagula Sai Deepak
Citi Neuro Centre
Outcome results
None listed