Pain control during lower wisdom tooth removal using two different local anaesthesia techniques.

A randomized clinical trial comparing the effectiveness of intraligamentary and infiltration anesthesia techniques versus inferior alveolar nerve block using four percent articaine for intraoperative pain management in partially erupted mandibular third molar surgery - A-LINE Trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/098438

Enrollment

Registered

2025-12-04

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intraligamentary + Buccal Infiltration Anesthesia using 4% Articaine: Intraligamentary anesthesia administered using 4% articaine with 1:100,000 adrenaline at the distal and mesial peri

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with partially erupted mandibular third molars indicated for surgical removal 2.ASA I or II healthy individuals 3.Patients willing to participate and provide informed consent 4.Patients aged 18-40 years

Exclusion criteria

Exclusion criteria: 1.Patients with acute infections at the surgical site(acute pathology) 2.Known allergy or hypersensitivity to articaine or any local anesthetic. 3.Pregnant or lactating women 4.Patients on anticoagulants or with bleeding disorders

Design outcomes

Primary

Measure	Time frame
Intraoperative pain perception measured using a 10-point Visual Analog Scale (VAS).Timepoint: Time Points: Baseline (before anaesthesia), Immediately after administration of anaesthesia(T1), During incision(T2), During bone removal(T3), During tooth elevation(T4), Immediately after completion of the procedure.	—

Secondary

Measure	Time frame
Onset time of anesthesia (in seconds).Timepoint: Measured immediately after injection until achievement of soft-tissue numbness (recorded in seconds)	—

Countries

India

Contacts

Public ContactAfsana Ahmed

Meenakshi Ammal Dental College and Hospital

anantparam@gmail.com9840052670

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026