Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Nebulized Magnesium Sulphate: Magnesium Sulphate 30mg/kg given through nebulization mask in pre operative room.
Control Intervention1: Intravenous Magnesium Sulphate: IV Magnesium Sulph
Sponsors
Ramaiah Medical College
Eligibility
Inclusion criteria
Inclusion criteria: Aged 18 65 years with American Society of Anaesthesiologists classification I-II Scheduled for elective surgery under general anaesthesia with endotracheal tube insertion.
Exclusion criteria
Exclusion criteria: Anticipated difficult laryngoscopy and intubation Patient with cardiovascular dysfunction or arrythmias Hepatic or renal impairment Neuromuscular disorder Raised intracranial pressure or intraocular pressure Presence of preoperative oral ulcer, sore throat, pharyngitis Pregnant patients Patients allergic to magnesium sulphate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure [MAP] and Heart Rate [HR]Timepoint: Mean arterial pressure [MAP] and Heart Rate [HR] at baseline, at the time of study drug administration, 5, 10, and 15 minutes after starting administration of the study drug, before induction, at the time of laryngoscopy, just after intubation, and 1, 5, and 10 minutes after intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of propofol consumptionTimepoint: During the induction of anaesthesia;Incidence of Sore ThroatTimepoint: Post Operative;Any adverse effects of magnesium sulphate, such as intraoperative bradycardia [HR 30 percentage fall from baseline, more more than 20 percentage fall in MAP from baseline], and postoperative nausea, vomiting, or respiratory depression.Timepoint: Intra and Post Operative | — |
Countries
India
Contacts
Public ContactDr Yatish B
Ramaiah Medical College
Outcome results
None listed