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A CLINICAL STUDY TO COMPARE CHITOSAN, PROBIOTIC, AND HERBAL MOUTHWASHES FOR REDUCING PLAQUE AND BACTERIA IN CHILDREN AT HIGH RISK OF TOOTH DECAY

COMPARATIVE EVALUATION OF CHITOSAN, PROBIOTIC AND HERBAL MOUTHWASHES IN TERMS OF DENTAL PLAQUE LEVELS AND ANTIBACTERIAL EFFECT IN CHILDREN WITH HIGH CARIES RISK - A RANDOMIZED CONTROLLED TRIAL - NIL

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/098387
Enrollment
80
Registered
2025-12-03
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: chitosan mouthwash: Chitosan is a natural material derived from the exoskeleton of marine invertebrates such as shrimp and crabs. It has several benefits, including biocompatibility, bi

Sponsors

Nehal Sarda
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Children of age between 7-12 yrs. Children with positive and definitely positive Frankl behaviour. Children with Good systemic health, no antibiotic or probiotic intake within the past 2 weeks before the study onset. Children with Absence of oral habits.

Exclusion criteria

Exclusion criteria: Children who recently underwent topical fluoride application. Children undergoing any surgical treatment Children having a history of allergy to any of the components used in the mouthrinse. Children whose parents/guardians/heads of the institution have not consented for permission. Children with systemic diseases, immune-compromising conditions, and special children Children undergoing any orthodontic treatment or wearing any orthodontic appliances.

Design outcomes

Primary

MeasureTime frame
There is a significant difference in the effect of chitosan based, probiotic and herbal mouthwash on the dental plaque levels and counts of Streptococcus mutans and Streptococcus salivarius among high-caries-risk children aged 7 to 12 years.Timepoint: 15 days, 1 month

Secondary

MeasureTime frame
There is no significant difference in the effect of chitosan based, probiotic, and herbal mouthwash on the dental plaque levels and counts of Streptococcus mutans and Streptococcus salivarius among high-caries-risk children aged 7 to 12 years.Timepoint: 15 days, 1 month

Countries

India

Contacts

Public ContactNehal Sarda

Affiliation Maharashtra Institute of Dental Sciences and Research, Latur, Maharashtra

nehalsarda.10@gmail.com8830404889

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026