A study comparing injection-based treatment (hyaluronic acid) and routine physiotherapy exercises on knee pain and inflammation in patients with knee osteoarthritis.

Comparison of Effect on Serum Inflammatory Markers Following Viscosupplementation Versus Conventional Management in Knee Osteoarthritis - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/098365

Enrollment

118

Registered

2025-12-03

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Intra-articular High Molecular Weight Hyaluronic Acid (HMW-HA): Participants in the intervention arm will receive a single intra-articular injection of High Molecular Weight Hyaluronic

Eligibility

Inclusion criteria

Inclusion criteria: Adults of either gender with primary tibiofemoral knee osteoarthritis fulfilling ACR clinical and radiographic criteria, radiographic Kellgren Lawrence grade II or III, and body mass index less than 40, who are willing to provide written informed consent.

Exclusion criteria

Exclusion criteria: History of bleeding disorders; any acute injury or recent surgery within the past three months; use of anti-inflammatory drugs for more than seven days in the past four weeks or within five days before starting the trial; current use of corticosteroids or immunosuppressive drugs; presence of any acute co-existing illness; prior hyaluronic acid injection or unwillingness to receive hyaluronic acid; any overlying skin infection; venous or lymphatic stasis.

Design outcomes

Primary

Measure	Time frame
Timepoint:	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Ishita

Vardhman Mahavir Medical College and Safdarjung hospital

dragupta2013@gmail.com9899675868

Outcome results