Can using microneedling to stimulate blood flow in the gums, along with injectable and concentrated platelet-rich fibrin, help increase gum thickness

Comparative Evaluation Of The Efficacy Of Microneedling With The Injectable Platelet- Rich Fibrin Versus Microneedling With The Concentrated Platelet-Rich Fibrin In The Management Of The Thin Gingival Phenotype - A Split Mouth Randomized Clinical Trial. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/098272

Enrollment

Registered

2025-12-01

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K055- Other periodontal diseases

Interventions

Intervention1: Microneedling with the injectable platelet rich fibrin.The procedure will be carried out after every 7 days for 3 sessions.: 1)11 patients with thin gingival phenotype will be treated w

Eligibility

Inclusion criteria

Inclusion criteria: Patients in the age group 18 to 45 years from both genders without any blood disorder willing to undergo treatment with informed consent were included Sites with thin gingival phenotype gingival thickness less than 1 point 5mm in maxillary and mandibular canine and premolar region Plaque index PI less than 1 Gingival index GI less than 1 Bleeding on probing score of less than 10 percent will be included in the study

Exclusion criteria

Exclusion criteria: Patients undergoing active orthodontic treatment Taking any medication that may cause gingival enlargement Bruxism Any previous history of periodontitis or periodontal therapy Pregnant or lactating women Use of tobacco in any form Taking any blood thinners Patients under Aspirin medication Pre-existing mucogingival deformities

Design outcomes

Primary

Measure	Time frame
The aim of the study is to compare and evaluate the efficacy of microneedling with the injectable platelet-rich fibrin versus microneedling with the concentrated platelet-rich fibrin in the management of the thin gingival phenotypeTimepoint: The outcome is assessed at baseline 3 months and 6 months	—

Secondary

Measure	Time frame
1)To assess the Gingival thickness following microneedling with i-PRF & microneedling with C-PRF in thin gingival phenotype. 2)To assess the Keratinized tissue width following microneedling with i-PRF & microneedling with C-PRF in thin gingival phenotype 3)To compare the Gingival thickness following microneedling with i-PRF & microneedling with C-PRF in thin gingival phenotype. 4)To compare the Keratinized tissue width following microneedling with i-PRF & microneedling with C-PRF in thin gingival phenotype.Timepoint: The outcome is assessed at baseline 3 months & 6 months	—

Measure

Time frame

1)To assess the Gingival thickness following microneedling with i-PRF & microneedling with C-PRF in thin gingival phenotype. 2)To assess the Keratinized tissue width following microneedling with i-PRF & microneedling with C-PRF in thin gingival phenotype 3)To compare the Gingival thickness following microneedling with i-PRF & microneedling with C-PRF in thin gingival phenotype. 4)To compare the Keratinized tissue width following microneedling with i-PRF & microneedling with C-PRF in thin gingival phenotype.Timepoint: The outcome is assessed at baseline 3 months & 6 months

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Countries

India

Contacts

Public ContactDr M M Dayakar

KVG Dental college and hospital

mmdayakar@yahoo.com9448167427

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026