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Comparing the analgesic effect of two different drugs (dexmedetomidine vs dexamethasone) used in combination with levobupivacaine in patients undergoing keyhole abdominal surgeries under general anaesthesia.

A randomised, prospective, double blinded study to compare the efficacy of dexmedetomidine vs dexamethasone as adjuvants to levobupivacaine in ultrasound guided transversus abdominis plane block in patients undergoing laparoscopic surgeries under general anaesthesia. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/098170
Enrollment
70
Registered
2025-11-27
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 0.125% Levobupivacaine 80ml + Dexmedetomidine 50mcg: Used in ultrasound guided TAP block (regional) stat dose in 4 sites (bilateral subcostal and lateral) in equally divided dose given

Sponsors

Nil
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Asa grade 1 and 2, weight 40 to 90 kg, BMI 18 to 30, Patients admitted for laparoscopic surgery,No history of allergy to any local anaesthetic or drug used in the study

Exclusion criteria

Exclusion criteria: ASA grade 3 to 5, Pregnant or lactating mother, History of allergy to local anaesthetics or any drug used in the study, Patient refusal

Design outcomes

Primary

MeasureTime frame
To observe post operative pain score (VAS) during the first 24hrs, To observe time to rescue analgesia and the total requirement of rescue analgesia ( Tramadol) during 24hrsTimepoint: To observe post operative pain score (VAS) during the first 24hrs, To observe time to rescue analgesia and the total requirement of rescue analgesia ( Tramadol) during 24hrs—

Secondary

MeasureTime frame
To observe the incidence of hemodynamic parameters during perioperative period, To observe incidence of adverse effect of opioids such as postoperative nausea, vomiting, respiratory depressionTimepoint: Intraoperatively ( during surgery), 24 hours post operatively (after surgery)—

Countries

India

Contacts

Public ContactDr Sathyan Prakasan

SIMS HOSPITAL

anaes1879@yahoo.com97909 30134

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026