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Comparing three teeth whitening products without peroxide that people commonly buy without a prescription.

Comparative clinical evaluation of three different non-peroxide based teeth whitening agents in those seeking over the counter treatment - A randomised clinical study. - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/098131
Enrollment
54
Registered
2025-11-26
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K037- Posteruptive color changes of dental hard tissues

Interventions

Intervention1: Papain and bromelaine based teeth whitening: Papain and bromelaine based teeth whitening done using Perfora purple magic teeth whitening serum. Let it sit on the teeth for 60 seconds an

Sponsors

Dr Manalee Mapara
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy patients (Category: American Society of Anaesthesiologists class 1 (ASA House of Delegates 2014)32 aged 18-35yr both male and female patients will be included in the study. 2. Patient having Good/general oral hygiene will be included. 3. Patients with chief complain of mild extrinsic discoloration or staining of teeth. 4. Patient with vital teeth giving normal positive response on cold and EPT testing will be included in the study. 5. Patients with no history of teeth sensitivity will be included. 6. A written informed consent will be taken from all the patients and only those patients ready to sign the consent form will be included in the study. 7. Only those patients who are willing to take teeth whitening treatment will be included in this study.

Exclusion criteria

Exclusion criteria: 1. Patients having habit of smoking or tobacco chewing will be excluded from study. 2. Patients having intrinsic staining of teeth will be excluded from study. 3. Patients having parafunctional habits will be excluded from study. 4. Patients undergoing orthodontic treatment will be excluded from study. 5. Patients having previous restoration on anterior teeth will be excluded from study. 6. Patients with previous use of teeth bleaching or teeth whitening agent will be excluded from study. 7. Patients having known allergies to any product ingredients will be excluded from study. 8. Pregnant and lactating patients will be excluded from study. 9. Patients having periodontitis and poor oral hygiene will be excluded from the study.

Design outcomes

Primary

MeasureTime frame
Help to identify and compare the effectiveness, onset of action, and safety profiles of different non-peroxide-based teeth whitening agents specifically, PAP+HA-based, charcoal-based, and papain and bromelain enzyme-based formulations. It is expected to reveal which agent provides the most noticeable and rapid whitening effect with minimal side effects like sensitivity or irritation.Timepoint: After 15 days

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDr Nimisha Shah

K M Shah dental college and hospital

nshah7873@gmail.com9998994299

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026